P028 Telomere shortening and genetic anticipation in IBD
نویسندگان
چکیده
منابع مشابه
AB181. Telomere shortening is associated with genetic anticipation in Chinese Von Hippel-Lindau disease families
Objective: Von Hippel-Lindau (VHL) disease is a rare autosomal dominant cancer syndrome. A phenomenon known as genetic anticipation has been documented in some hereditary cancer syndromes, where it was proved to relate to telomere shortening. Because studies of this phenomenon in VHL disease have been relatively scarce, we investigated anticipation in 18 Chinese VHL disease families. Methods: W...
متن کاملGenetic Anticipation Is Associated with Telomere Shortening in Hereditary Breast Cancer
There is increasing evidence suggesting that short telomeres and subsequent genomic instability contribute to malignant transformation. Telomere shortening has been described as a mechanism to explain genetic anticipation in dyskeratosis congenita and Li-Fraumeni syndrome. Since genetic anticipation has been observed in familial breast cancer, we aimed to study telomere length in familial breas...
متن کاملTelomere shortening is associated with genetic anticipation in Chinese Von Hippel-Lindau disease families.
Von Hippel-Lindau (VHL) disease is a rare autosomal dominant cancer syndrome. A phenomenon known as genetic anticipation has been documented in some hereditary cancer syndromes, where it was proved to relate to telomere shortening. Because studies of this phenomenon in VHL disease have been relatively scarce, we investigated anticipation in 18 Chinese VHL disease families. We recruited 34 paren...
متن کاملTelomere Length and Genetic Anticipation in Lynch Syndrome
Telomere length variation has been associated with increased risk of several types of tumors, and telomere shortening, with genetic anticipation in a number of genetic diseases including hereditary cancer syndromes. No conclusive studies have been performed for Lynch syndrome, a hereditary colorectal cancer syndrome caused by germline mutations in the DNA mismatch repair genes. Here we evaluate...
متن کاملRapid telomere shortening in children.
Telomere shortening may reflect the total number of divisions experienced by a somatic cell and is associated with replicative senescence. We found that the average rate of telomere shortening in peripheral blood mononuclear cells (PBMCs) obtained longitudinally from nine different infants during the first 3 years of life (270 bp per year) is more than fourfold higher than in adults and does no...
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ژورنال
عنوان ژورنال: Journal of Crohn's and Colitis
سال: 2019
ISSN: 1873-9946,1876-4479
DOI: 10.1093/ecco-jcc/jjy222.152